中文名称

13C6-葡萄糖基鞘氨醇

英文名字

13C6-Glucosylsphingosine

供应商

Matreya

欧宝体育官方 货号

2209-1

欧宝体育官方 报价

￥询价/1mg欧宝体育官方:

欧宝体育官方 说明书

购买方式

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背景资料

Glucosylsphingosine is the lyso-derivative of the common glycolipid glucocerebroside. This product is a stable isotope labeled standard containing six carbon-13 units on the glucose moiety. Glucosylceramide and glucosylsphingosine are important biological species that are the precursors for many complex glycosphingolipids. These lipids are involved in critical cellular functions such as cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. One of the most important roles of glucosylsphingosine is as a biomarker for the lysosomal storage disorder Gaucher disease. Gaucher disease is characterized by an accumulation of glucocerebroside due to a deficiency in the enzyme glucocerebrosidase and it has now been found that glucosylsphingosine also accumulates in this disease.1 This accumulation of glucosylsphingosine contributes to neuronal dysfunction and destruction in patients with neuronopathic Gaucher disease2 and it has been found to be a potent inhibitor of glucocerebrosidase. At least some instances of Gaucher disease also have a deficiency in the activity of glucopsychosine beta-glucosidase, the enzyme responsible for cleaving off the glucose of glucopsychosine and glucocerebroside. Like glucocerebroside and galactocerebroside, glucosylsphingosine can increase Ca2 + mobilization from intracellular stores although it uses a different mechanism.3 Conduritol B epoxide (CBE), an inhibitor of beta-glucosidase, and l-phenyl-2-decanoylamino-3-morpholino-l-propanol (PDMP), an inhibitor of glucosylceramide synthase, can be used to create a model of Gaucher disease and consequently an accumulation of glucosylsphingosine.4

欧宝体育官方 描述

13C6-lyso-glucocerebroside|1-(beta-D-Glucosyl-1,2,3,4,5,6-13C6)-sphingosine

欧宝体育官方 形式

该13C6-葡萄糖基鞘氨醇欧宝体育官方 为固体形式

保存建议

对于本欧宝体育官方 ，欧宝体育官方 推荐使用-20℃蓝冰低温进行运输。在您收到货物后，欧宝体育官方 建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他

Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的欧宝体育官方 具有最佳纯度。 Matreya欧宝体育官方 线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质欧宝体育官方 最全的供应商之一。欧宝体育官方 涉及生物化学、制药、微生物学、食品和农业等研究领域。

注意

该页面的中文欧宝体育官方 信息的翻译，仅供参考。准确的欧宝体育官方 信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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